Pub. Date : 2020 Nov
PMID : 32758585
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Novel aspects of glutamine synthetase in ammonia homeostasis. | Ammonia | glutamate-ammonia ligase | Homo sapiens |
| 2 | Ammonia is cleared via two main mechanisms, the urea cycle pathway and the glutamine synthetase reaction. | Ammonia | glutamate-ammonia ligase | Homo sapiens |
| 3 | While the liver clears about two-thirds of the body"s ammonia via the combined action of the urea cycle and glutamine synthetase, extrahepatic tissues do not express all the components required for performing a complete urea cycle and therefore depend on the glutamine synthetase reaction for ammonia clearance. | Ammonia | glutamate-ammonia ligase | Homo sapiens |
| 4 | This review discusses the emerging roles of glutamine synthetase in brain pathophysiology, particularly aspects related to ammonia homeostasis and hepatic encephalopathy. | Ammonia | glutamate-ammonia ligase | Homo sapiens |