Title : Activation orexin 1 receptors in the ventrolateral periaqueductal gray matter attenuate nitroglycerin-induced migraine attacks and calcitonin gene related peptide up-regulation in trigeminal nucleus caudalis of rats.

Pub. Date : 2020 Nov 1

PMID : 32745488






2 Functional Relationships(s)
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1 Besides, OrxA (100 pM) decreased NTG-induced CGRP upregulation. Nitroglycerin calcitonin-related polypeptide alpha Rattus norvegicus
2 The data revealed that the activation of Orx1Rs in the vlPAG is effective in relieving NTG-induced migraine symptoms mainly by the downregulation of CGRP in the Vc of rats. Nitroglycerin calcitonin-related polypeptide alpha Rattus norvegicus