Pub. Date : 2020 Jul 31
PMID : 32736525
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake. | Tacrolimus | lymphatic vessel endothelial hyaluronan receptor 1 | Homo sapiens |
| 2 | Flow cytometry was used to examine the effects of FK506 on LYVE-1 in precision-cut-lung-slices ex vivo and on hyaluronan uptake in vitro. | Tacrolimus | lymphatic vessel endothelial hyaluronan receptor 1 | Homo sapiens |
| 3 | Treatment with FK506 decreased LYVE-1 mRNA and protein levels and resulted in decreased LEC HA uptake. | Tacrolimus | lymphatic vessel endothelial hyaluronan receptor 1 | Homo sapiens |
| 4 | Similar result showing reduction of LYVE-1 expression when treated with FK506 was observed ex vivo. | Tacrolimus | lymphatic vessel endothelial hyaluronan receptor 1 | Homo sapiens |
| 5 | We showed that this NFAT binding site regulates LYVE-1 transcription, and mutation of this binding site blunted FK506-dependent downregulation of LYVE-1 promoter-dependent transcription. | Tacrolimus | lymphatic vessel endothelial hyaluronan receptor 1 | Homo sapiens |
| 6 | We showed that this NFAT binding site regulates LYVE-1 transcription, and mutation of this binding site blunted FK506-dependent downregulation of LYVE-1 promoter-dependent transcription. | Tacrolimus | lymphatic vessel endothelial hyaluronan receptor 1 | Homo sapiens |