Title : Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice.

Pub. Date : 2020 Oct 1

PMID : 32735318






2 Functional Relationships(s)
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1 Treatment of humanized CAR and pregnane X receptor (PXR) mice (hCAR/hPXR mice) with 1000 ppm PB for 7 days significantly increased hepatocyte RDS together with increases in several mitogenic genes. Phenobarbital nuclear receptor subfamily 1, group I, member 2 Mus musculus
2 Treatment of humanized CAR and pregnane X receptor (PXR) mice (hCAR/hPXR mice) with 1000 ppm PB for 7 days significantly increased hepatocyte RDS together with increases in several mitogenic genes. Phenobarbital nuclear receptor subfamily 1, group I, member 2 Mus musculus