Title : Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice.

Pub. Date : 2020 Oct 1

PMID : 32735318






1 Functional Relationships(s)
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1 Global gene expression analysis was performed with liver samples from this and from previous studies focusing on PB-induced Wnt/beta-catenin signaling, and showed that altered genes in hCAR/hPXR mice clustered most closely with liver tumor samples from a diethylnitrosamine/PB initiation/promotion study than with wild type mice. Phenobarbital catenin (cadherin associated protein), beta 1 Mus musculus