Pub. Date : 2020 Oct 1
PMID : 32730838
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 3-Methylcholanthrene (3-MC), benz[a]anthracene (B[a]A), benzo[a]pyrene (B[a]P), and valproic acid (VPA) increased the expression of CYP1B1 and CYP1A1. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | The potent aryl hydrocarbon receptor antagonist GNF351 significantly suppressed the 3-MC- and VPA-mediated upregulation of CYP1B1 and CYP1A1. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | In addition, VPA potentiated the induction of CYP1B1 and CYP1A1 by 3-MC, B[a]A, and B[a]P, although the augmentation of CYP1A1 was more remarkable than that of CYP1B1. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | Therefore, the effects of trichostatin A, a representative HDAC inhibitor, on CYP1 induction by 3-MC were examined. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 5 | Trichostatin A enhanced the 3-MC-mediated upregulation of CYP1A1 but not CYP1B1. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |