Title : Design, synthesis, biological evaluation and in silico studies of novel pyrrolo[3,4-d]pyridazinone derivatives withpromising anti-inflammatory and antioxidant activity.

Pub. Date : 2020 Sep

PMID : 32721780






2 Functional Relationships(s)
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1 Moreover, every examined derivative of pyrrolo[3,4-d]pyridazinone demonstrates better inhibitory activity towards COX-2 and a superior COX-2/COX-1 selectivity ratio compared to the reference drug meloxicam. Meloxicam mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Moreover, every examined derivative of pyrrolo[3,4-d]pyridazinone demonstrates better inhibitory activity towards COX-2 and a superior COX-2/COX-1 selectivity ratio compared to the reference drug meloxicam. Meloxicam mitochondrially encoded cytochrome c oxidase II Homo sapiens