Title : GLP1R Single-Nucleotide Polymorphisms rs3765467 and rs10305492 Affect β Cell Insulin Secretory Capacity and Apoptosis Through GLP-1.

Pub. Date : 2020 Sep

PMID : 32721233






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1 In this study, we revealed that two SNPs in GLP1R gene, rs3765467 and rs10305492, could significantly reduce the insulin secreted by beta cells and the cyclic AMP concentration, whereas promote beta cell apoptosis. Cyclic AMP insulin Homo sapiens