Pub. Date : 2020 Jan-Dec
PMID : 32718263
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BA treatment also decreased serum interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) levels in rats with CIA. | betulinic acid | tumor necrosis factor | Rattus norvegicus |
| 2 | BA treatment also decreased serum interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) levels in rats with CIA. | betulinic acid | tumor necrosis factor | Rattus norvegicus |
| 3 | BA significantly inhibited TNF-alpha-stimulated RA-FLS proliferation, as well as IL-1beta and IL-6 secretion. | betulinic acid | tumor necrosis factor | Rattus norvegicus |
| 4 | BA also downregulated the transcription of vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGF-beta) and decreased the expression of the NF-kB pathway proteins (NF-kB-P65, IkBalpha, and IKKalpha/beta) in the TNF-alpha-stimulated RA-FLS. | betulinic acid | tumor necrosis factor | Rattus norvegicus |
| 5 | These results indicate that BA alleviated the symptoms of CIA by inhibiting synoviocyte proliferation, modifying TNF-alpha- and NF-kB-related inflammatory pathways, and downregulating inflammatory mediators and growth factors including IL-1beta, IL-6, VEGF, and TGF-beta. | betulinic acid | tumor necrosis factor | Rattus norvegicus |