Title : Cbl Negatively Regulates NLRP3 Inflammasome Activation through GLUT1-Dependent Glycolysis Inhibition.

Pub. Date : 2020 Jul 19

PMID : 32707731






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Upon NLRP3 inflammasome activation, inhibiting Cbl increased glycolysis-dependent activation of mitochondrial respiration and increased the production of reactive oxygen species, which contributes to NLRP3 inflammasome activation and IL-1beta secretion. Oxygen NLR family pyrin domain containing 3 Homo sapiens