Title : Cbl Negatively Regulates NLRP3 Inflammasome Activation through GLUT1-Dependent Glycolysis Inhibition.

Pub. Date : 2020 Jul 19

PMID : 32707731






1 Functional Relationships(s)
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1 Mechanistically, inhibiting Cbl increased surface expression of glucose transporter 1 (GLUT1) protein through post-transcriptional regulation, which increased cellular glucose uptake and consequently raised glycolytic capacity, and in turn enhanced NLRP3 inflammasome activation. Glucose NLR family pyrin domain containing 3 Homo sapiens