Pub. Date : 2021
PMID : 32705888
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Genistein Suppresses v-Src-Driven Proliferative Activity by Arresting the Cell-Cycle at G2/M through Increasing p21 Level in Src-Activated Human Gallbladder Carcinoma cells. | Genistein | H3 histone pseudogene 16 | Homo sapiens |
2 | Genistein increased the expression levels of p53 and p21 with decreased phosphorylated p21, but did not affect the levels of major cyclin-CDK complexes. | Genistein | H3 histone pseudogene 16 | Homo sapiens |
3 | Genistein increased the expression levels of p53 and p21 with decreased phosphorylated p21, but did not affect the levels of major cyclin-CDK complexes. | Genistein | H3 histone pseudogene 16 | Homo sapiens |
4 | Taken together, genistein would be considered as the only isoflavone component that may potentially suppress Src-driven proliferative activity by arresting at G2/M induction through increasing the p21 levels, thus providing the mechanistic rationale for the potential use of genistein for the prevention of human cancers with activated Src. | Genistein | H3 histone pseudogene 16 | Homo sapiens |