Title : Autocrine C-peptide protects INS1 β cells against palmitic acid-induced oxidative stress in peroxisomes by inducing catalase.

Pub. Date : 2020 Jul

PMID : 32704568






6 Functional Relationships(s)
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1 Aims: C-peptide, produced by pancreatic beta cells and co-secreted in the bloodstream with insulin, has antioxidant properties in glucose- and hydrogen peroxide (H2O2)-exposed INS1 beta cells. Hydrogen Peroxide insulin 2 Rattus norvegicus
2 Aims: C-peptide, produced by pancreatic beta cells and co-secreted in the bloodstream with insulin, has antioxidant properties in glucose- and hydrogen peroxide (H2O2)-exposed INS1 beta cells. Hydrogen Peroxide insulin 2 Rattus norvegicus
3 To study the ability of C-peptide to lower peroxisomal H2O2, we engineered an INS1 beta cell line stably expressing the peroxisomal-targeted H2O2 sensor HyPer, whose fluorescence increases with cellular H2O2. Hydrogen Peroxide insulin 2 Rattus norvegicus
4 To study the ability of C-peptide to lower peroxisomal H2O2, we engineered an INS1 beta cell line stably expressing the peroxisomal-targeted H2O2 sensor HyPer, whose fluorescence increases with cellular H2O2. Hydrogen Peroxide insulin 2 Rattus norvegicus
5 To study the ability of C-peptide to lower peroxisomal H2O2, we engineered an INS1 beta cell line stably expressing the peroxisomal-targeted H2O2 sensor HyPer, whose fluorescence increases with cellular H2O2. Hydrogen Peroxide insulin 2 Rattus norvegicus
6 Results: C-peptide protects INS1 beta cells from the combined effect of palmitic acid and glucose by reducing peroxisomal H2O2 to baseline levels and increasing expression of catalase. Hydrogen Peroxide insulin 2 Rattus norvegicus