Title : Oral quetiapine treatment results in time-dependent alterations of recognition memory and brain-derived neurotrophic factor-related signaling molecules in the hippocampus of rats.

Pub. Date : 2020 Oct

PMID : 32702397






3 Functional Relationships(s)
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1 Oral quetiapine treatment results in time-dependent alterations of recognition memory and brain-derived neurotrophic factor-related signaling molecules in the hippocampus of rats. Quetiapine Fumarate brain-derived neurotrophic factor Rattus norvegicus
2 The purpose of the studies described here was to evaluate one of the most commonly prescribed APDs, quetiapine, for chronic effects on recognition memory, brain-derived neurotrophic factor (BDNF), its precursor proBDNF, as well as relevant downstream signaling molecules that are known to influence neuronal plasticity and cognition. Quetiapine Fumarate brain-derived neurotrophic factor Rattus norvegicus
3 The results indicated that oral quetiapine at a dose that did not induce catalepsy, led to time-dependent impairments in NOR performance, increases in the proBDNF/BDNF ratio, and decreases in Akt and CREB phosphorylation in the hippocampus. Quetiapine Fumarate brain-derived neurotrophic factor Rattus norvegicus