Title : Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro.

Pub. Date : 2020 Sep 18

PMID : 32699847






2 Functional Relationships(s)
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1 Here we use murine leukemia viruses pseudotyped with Spike from SARS-CoV or SARS-CoV-2 to demonstrate that ACE2-mediated coronavirus entry can be mitigated by heparin, a heparan sulfate-related glycan, or by genetic ablation of biosynthetic enzymes for the cell surface heparan sulfate proteoglycans (HSPGs). Heparitin Sulfate angiotensin converting enzyme 2 Homo sapiens
2 Here we use murine leukemia viruses pseudotyped with Spike from SARS-CoV or SARS-CoV-2 to demonstrate that ACE2-mediated coronavirus entry can be mitigated by heparin, a heparan sulfate-related glycan, or by genetic ablation of biosynthetic enzymes for the cell surface heparan sulfate proteoglycans (HSPGs). Heparitin Sulfate angiotensin converting enzyme 2 Homo sapiens