Pub. Date : 2020 Jun
PMID : 32696742
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Palmitic acid decreases phosphorylation of eNOS Ser1177 by activating protein phosphatase 2C (PP2C) of human umbilical vein endothelial cells]. | Palmitic Acid | nitric oxide synthase 3 | Homo sapiens |
| 2 | Objective To investigate the roles of protein phosphatase 2C (PP2C) activated by palmitic acid (PA) in the phosphorylation modulation of endothelial nitric oxide (eNOS) at the site of serine 1177 (eNOS Ser1177) in human umbilical vein endothelial cells (HUVECs). | Palmitic Acid | nitric oxide synthase 3 | Homo sapiens |
| 3 | Objective To investigate the roles of protein phosphatase 2C (PP2C) activated by palmitic acid (PA) in the phosphorylation modulation of endothelial nitric oxide (eNOS) at the site of serine 1177 (eNOS Ser1177) in human umbilical vein endothelial cells (HUVECs). | Palmitic Acid | nitric oxide synthase 3 | Homo sapiens |
| 4 | Objective To investigate the roles of protein phosphatase 2C (PP2C) activated by palmitic acid (PA) in the phosphorylation modulation of endothelial nitric oxide (eNOS) at the site of serine 1177 (eNOS Ser1177) in human umbilical vein endothelial cells (HUVECs). | Palmitic Acid | nitric oxide synthase 3 | Homo sapiens |
| 5 | Results Compared with the control group, the phosphorylation levels of eNOS Ser1177 and NO content decreased significantly in the PA group. | Palmitic Acid | nitric oxide synthase 3 | Homo sapiens |
| 6 | The PP2C inhibitor sanguinarine reversed PA-induced decrease of eNOS Ser1177 phosphorylation level and NO content. | Palmitic Acid | nitric oxide synthase 3 | Homo sapiens |
| 7 | Conclusion PA reduces the phosphorylation level of endothelial eNOS Ser1177 in HUVECs by activating PP2C. | Palmitic Acid | nitric oxide synthase 3 | Homo sapiens |