Title : Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization.

Pub. Date : 2020

PMID : 32692785






2 Functional Relationships(s)
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1 We found that TBB (a casein kinase II inhibitor), AR and LiCl (GSK-3 inhibitors), cyclosporin A (calcineurin inhibitor), and Saracatinib (Fyn kinase inhibitor) caused robust inhibition of OA-induced monomeric and oligomeric p-tau in both N2a and CTX culture. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate microtubule associated protein tau Homo sapiens
2 This study provides a comprehensive view of potential drug candidates (TBB, CsA, AR, and Saracatinib), and their efficacy against tau hyperphosphorylation and oligomerization processes. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate microtubule associated protein tau Homo sapiens