Title : Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype.

Pub. Date : 2020 Nov

PMID : 32686475






1 Functional Relationships(s)
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1 Here we demonstrate that the SASP regulation is linked to shifts in intracellular Ca2+ homeostasis and strategies which rescue redox-dependent calcium entry including enzymatic H2O2 scavenging, TRP modulation, or mTOR inhibition block SASP and TRPC6 gene expression. Hydrogen Peroxide transient receptor potential cation channel subfamily C member 6 Homo sapiens