Title : Female-specific activation of pregnane X receptor mediates sex difference in fetal hepatotoxicity by prenatal monocrotaline exposure.

Pub. Date : 2020 Nov 1

PMID : 32682830






1 Functional Relationships(s)
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1 While in male, during the intrauterine period, activated AR by testosterone secretion from developing testes represses MCT-induced PXR activation and CYP3A induction, which may partially protect male fetus from MCT-induced hepatotoxicity. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens