Title : Amplified Detection of Breast Cancer Autoantibodies Using MUC1-Based Tn Antigen Mimics.

Pub. Date : 2020 Aug 13

PMID : 32672464






3 Functional Relationships(s)
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1 In the present study, we focused on the MUC1 associated Tn antigen (alpha-O-GalNAc-Ser/Thr), and substituted the GalNAc monosaccharide by a glycomimic to identify MUC1 based glycopeptides with increased antigenicity. Glycopeptides mucin 1, cell surface associated Homo sapiens
2 The suitability of the sp2-iminosugar glycopeptides to detect anti-MUC1 antibodies was demonstrated and serological experiments showed stage I breast cancer autoantibodies binding with a specific unnatural glycopeptide with almost no healthy serum interaction. Glycopeptides mucin 1, cell surface associated Homo sapiens
3 The suitability of the sp2-iminosugar glycopeptides to detect anti-MUC1 antibodies was demonstrated and serological experiments showed stage I breast cancer autoantibodies binding with a specific unnatural glycopeptide with almost no healthy serum interaction. Glycopeptides mucin 1, cell surface associated Homo sapiens