Title : The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal Structure and DFT Studies.

Pub. Date : 2020 Jul 10

PMID : 32664320






1 Functional Relationships(s)
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1 Our DFT computational studies on the three natural products of the same coumarin family docked into the active site of CYP3A4 (PDB 4D78) show different behavior for these coumarins at the active site. coumarin cytochrome P450 family 3 subfamily A member 4 Homo sapiens