Title : The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal Structure and DFT Studies.

Pub. Date : 2020 Jul 10

PMID : 32664320






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Bergamottin is a furanocoumarin found in citrus plants, which is a strong inhibitor of the principal human metabolizing enzyme, cytochrome P450 3A4 (CYP3A4). Furocoumarins cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Bergamottin is a furanocoumarin found in citrus plants, which is a strong inhibitor of the principal human metabolizing enzyme, cytochrome P450 3A4 (CYP3A4). Furocoumarins cytochrome P450 family 3 subfamily A member 4 Homo sapiens