Title : Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer's disease-type pathology and cognitive deficits in APP/PS1 mice.

Pub. Date : 2020 Jul 13

PMID : 32661266






3 Functional Relationships(s)
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1 In the present study, we found that intake of capsaicin, the pungent ingredient in chili peppers, reduced brain Abeta burden and rescued cognitive decline in APP/PS1 mice. Capsaicin amyloid beta (A4) precursor protein Mus musculus
2 Our in vivo and in vitro studies revealed that capsaicin shifted Amyloid precursor protein (APP) processing towards alpha-cleavage and precluded Abeta generation by promoting the maturation of a disintegrin and metalloproteinase 10 (ADAM10). Capsaicin amyloid beta (A4) precursor protein Mus musculus
3 Our in vivo and in vitro studies revealed that capsaicin shifted Amyloid precursor protein (APP) processing towards alpha-cleavage and precluded Abeta generation by promoting the maturation of a disintegrin and metalloproteinase 10 (ADAM10). Capsaicin amyloid beta (A4) precursor protein Mus musculus