Pub. Date : 2020 Sep 1
PMID : 32651261
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | aKG esters also conferred cytotoxicity in a variety of cancer types if their cell respiration was obstructed by hypoxia or by chemical inhibition of the electron transport chain (ETC), both of which are known to increase aspartate and GOT1 dependencies. | Esters | glutamic-oxaloacetic transaminase 1, soluble | Mus musculus |
| 2 | SIGNIFICANCE: These findings demonstrate that OXPHOS deficiency caused by either hypoxia or mutations, which can significantly increase cancer virulence, renders tumors sensitive to aKG esters by targeting their dependence upon GOT1 for aspartate synthesis. | Esters | glutamic-oxaloacetic transaminase 1, soluble | Mus musculus |