Title : Synthesis, characterization, molecular docking, and biological activities of coumarin-1,2,3-triazole-acetamide hybrid derivatives.

Pub. Date : 2020 Oct

PMID : 32643792






3 Functional Relationships(s)
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1 In this study, a series of novel coumarin-1,2,3-triazole-acetamide hybrids was tested against some metabolic enzymes including alpha-glycosidase (alpha-Gly), alpha-amylase (alpha-Amy), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase I (hCA I), and hCA II. acetamide acetylcholinesterase (Cartwright blood group) Homo sapiens
2 In this study, a series of novel coumarin-1,2,3-triazole-acetamide hybrids was tested against some metabolic enzymes including alpha-glycosidase (alpha-Gly), alpha-amylase (alpha-Amy), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase I (hCA I), and hCA II. acetamide acetylcholinesterase (Cartwright blood group) Homo sapiens
3 The new coumarin-1,2,3-triazole-acetamide hybrids showed Ki values in the range of 483.50-1,243.04 nM against hCA I, 508.55-1,284.36 nM against hCA II, 24.85-132.85 nM against AChE, 27.17-1,104.36 nM against BChE, 590.42-1,104.36 nM against alpha-Gly, and 55.38-128.63 nM against alpha-Amy. acetamide acetylcholinesterase (Cartwright blood group) Homo sapiens