Title : Molecular Dynamics Simulations to Investigate How PZM21 Affects the Conformational State of the μ-Opioid Receptor Upon Activation.

Pub. Date : 2020 Jul 1

PMID : 32630190






1 Functional Relationships(s)
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1 To demonstrate a rationale for the reduced biasing agonism of PZM21 compared with that of TRV130 at the molecular level, we undertook a long-term molecular dynamics simulation of the mu-opioid receptor (MOR) upon the binding of three ligands: morphine, TRV130, and PZM21. Morphine opioid receptor mu 1 Homo sapiens