Title : The Sca-1+ and Sca-1- mouse prostatic luminal cell lineages are independently sustained.

Pub. Date : 2020 Nov

PMID : 32627901






4 Functional Relationships(s)
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1 We show that the Sca-1+ luminal cells at the mouse proximal prostate express Sox2. Phenobarbital SRY (sex determining region Y)-box 2 Mus musculus
2 Sox2 is dispensable for the maintenance of the Sca-1+ luminal cells but is essential for their facultative bipotent differentiation capacity. Phenobarbital SRY (sex determining region Y)-box 2 Mus musculus
3 AlphaMed Press 2020 SIGNIFICANCE STATEMENT: This study characterizes the phenotypic and functional heterogeneity of the mouse prostate luminal epithelial cells and demonstrates a critical role of Sox2 in maintaining the facultative bipotent differentiation capacity of the Sca-1+ luminal cells. Phenobarbital SRY (sex determining region Y)-box 2 Mus musculus
4 AlphaMed Press 2020 SIGNIFICANCE STATEMENT: This study characterizes the phenotypic and functional heterogeneity of the mouse prostate luminal epithelial cells and demonstrates a critical role of Sox2 in maintaining the facultative bipotent differentiation capacity of the Sca-1+ luminal cells. Phenobarbital SRY (sex determining region Y)-box 2 Mus musculus