Pub. Date : 2020 Aug 1
PMID : 32618512
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Progesterone promotes endothelial nitric oxide synthase expression through enhancing nuclear progesterone receptor-SP1 formation. | Progesterone | nitric oxide synthase 3 | Rattus norvegicus |
| 2 | Progesterone exerts antihypertensive actions partially by modulating endothelial nitric oxide synthase (eNOS) activity. | Progesterone | nitric oxide synthase 3 | Rattus norvegicus |
| 3 | Progesterone exerts antihypertensive actions partially by modulating endothelial nitric oxide synthase (eNOS) activity. | Progesterone | nitric oxide synthase 3 | Rattus norvegicus |
| 4 | Here, we aimed to investigate the effects and mechanisms of progesterone on eNOS expression. | Progesterone | nitric oxide synthase 3 | Rattus norvegicus |
| 5 | The results showed that Progesterone could increase eNOS expression in HUVECs. | Progesterone | nitric oxide synthase 3 | Rattus norvegicus |
| 6 | Further study showed that progesterone increased PR-A-SP1 complex formation and facilitated PR-A/B and SP1 binding to eNOS promoter. | Progesterone | nitric oxide synthase 3 | Rattus norvegicus |
| 7 | Mutating SP1 or PR binding motif on eNOS promoter abolished the effect of progesterone on eNOS gene transcription. | Progesterone | nitric oxide synthase 3 | Rattus norvegicus |
| 8 | Mutating SP1 or PR binding motif on eNOS promoter abolished the effect of progesterone on eNOS gene transcription. | Progesterone | nitric oxide synthase 3 | Rattus norvegicus |
| 9 | Those results suggest that progesterone modulates eNOS expression through promoting PR-A-SP1 complex formation and progesterone antagonist attenuates eNOS expression leading to the loss of vascular relaxation. | Progesterone | nitric oxide synthase 3 | Rattus norvegicus |
| 10 | Those results suggest that progesterone modulates eNOS expression through promoting PR-A-SP1 complex formation and progesterone antagonist attenuates eNOS expression leading to the loss of vascular relaxation. | Progesterone | nitric oxide synthase 3 | Rattus norvegicus |