Pub. Date : 2020 Sep
PMID : 32585319
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The bone morphogenetic protein (BMP)-SMAD signaling pathway plays a central role in regulating hepcidin, which is the master hormone governing systemic iron homeostasis. | Iron | SMAD family member 1 | Homo sapiens |
| 2 | Mutation or inactivation of BMP ligands, BMP receptors, HJV, SMADs or other proteins that modulate the BMP-SMAD pathway result in hepcidin dysregulation, leading to iron-related disorders, such as hemochromatosis and iron refractory iron deficiency anemia. | Iron | SMAD family member 1 | Homo sapiens |
| 3 | Pharmacologic modulators of the BMP-SMAD pathway have shown efficacy in pre-clinical models to regulate hepcidin expression and treat iron-related disorders. | Iron | SMAD family member 1 | Homo sapiens |
| 4 | This review will discuss recent insights into the role of the BMP-SMAD pathway in regulating hepcidin to control systemic iron homeostasis. | Iron | SMAD family member 1 | Homo sapiens |