Title : Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis Induction.

Pub. Date : 2020

PMID : 32581812






1 Functional Relationships(s)
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1 Mechanistically, we show that Shikonin arrested the cell cycle at the G2/M phase, inhibited the ERK-dependent cell growth signal, and induced cell death in both P53 wild type and mutant cancer cells, which collectively contributed to the growth inhibitory effect of Shikonin. shikonin mitogen-activated protein kinase 1 Homo sapiens