Title : Immune responses in beta-thalassaemia: heme oxygenase 1 reduces cytokine production and bactericidal activity of human leucocytes.

Pub. Date : 2020 Jun 24

PMID : 32581238






1 Functional Relationships(s)
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1 Induction of HO-1 by hemin or CoPP in vitro reduced production of IFN-gamma and IL-10 from healthy human PBMCs and decreased bacterial clearance activity of whole blood from healthy controls and beta-thalassaemia, while inhibition of HO-1 by SnPP enhanced both functions in healthy controls. S-Nitroso-N-propionyl-D,L-penicillamine heme oxygenase 1 Homo sapiens