Title : Sirt1 suppresses MCP-1 production during the intervertebral disc degeneration by inactivating AP-1 subunits c-Fos/c-Jun.

Pub. Date : 2020 Jun

PMID : 32572902






3 Functional Relationships(s)
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1 We induced nucleus pulposus (NP) cell degeneration by IL-1beta and mediated cellular Sirt1 expression through the Sirt1 activator resveratrol (Res) or inhibitor Nicotinamide (Nico). Niacinamide sirtuin 1 Homo sapiens
2 We induced nucleus pulposus (NP) cell degeneration by IL-1beta and mediated cellular Sirt1 expression through the Sirt1 activator resveratrol (Res) or inhibitor Nicotinamide (Nico). Niacinamide sirtuin 1 Homo sapiens
3 On the contrary, Sirt1 downregulation by Nico aggravated the phosphorylation of c-Fos/c-Jun and MCP-1 expression. Niacinamide sirtuin 1 Homo sapiens