Title : Distinct binding of cetirizine enantiomers to human serum albumin and the human histamine receptor H1.

Pub. Date : 2020 Oct

PMID : 32572668






1 Functional Relationships(s)
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1 At the histamine-binding site in hH1R, the distinct interactions established between the phenyl and chlorophenyl moieties of the two enantiomers with the amino acids lining up the pocket and between their free carboxylates and Lys179 in the second extracellular loop account for the improved pharmacological profile of (R)-cetirizine. Histamine histamine receptor H1 Homo sapiens