Title : Deletion of 2-aminoadipic semialdehyde synthase limits metabolite accumulation in cell and mouse models for glutaric aciduria type 1.

Pub. Date : 2020 Nov

PMID : 32567100






1 Functional Relationships(s)
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1 These in vivo data demonstrate that the saccharopine pathway is the main source of glutaric acid production in the brain and periphery of a mouse model for GA1, and support the notion that pharmacological inhibition of AASS may represent an attractive strategy to treat GA1. saccharopine aminoadipate-semialdehyde synthase Mus musculus