Pub. Date : 2020
PMID : 32566089
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Melatonin Antagonizes Nickel-Induced Aerobic Glycolysis by Blocking ROS-Mediated HIF-1alpha/miR210/ISCU Axis Activation. | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | Nickel and its compounds, which are well-documented carcinogens, induce the Warburg effect in normal cells by stabilizing hypoxia-inducible factor 1alpha (HIF-1alpha). | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | Nickel and its compounds, which are well-documented carcinogens, induce the Warburg effect in normal cells by stabilizing hypoxia-inducible factor 1alpha (HIF-1alpha). | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 4 | N-Acetylcysteine (NAC) manifested similar effects as melatonin in scavenging ROS, maintaining prolyl-hydroxylase activity, and mitigating HIF-1alpha transcriptional activity in nickel-exposed cells. | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 5 | Our results indicated that ROS generation contributed to nickel-caused HIF-1alpha stabilization and downstream signal activation. | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |