Title : Combined anti-fibrotic and anti-inflammatory properties of JAK-inhibitors on macrophages in vitro and in vivo: Perspectives for scleroderma-associated interstitial lung disease.

Pub. Date : 2020 Aug

PMID : 32562787






1 Functional Relationships(s)
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1 In this model, we showed that ruxolitinib significantly prevented the upregulation of pro-inflammatory M1 markers (TNFalpha, CXCL10, NOS2) and pro-fibrotic M2 markers (Arg1 and Chi3L3). ruxolitinib arginase 1 Homo sapiens