Title : CB1 receptor-dependent desensitisation of TRPV1 channels contributes to the analgesic effect of dipyrone in sensitised primary sensory neurons.

Pub. Date : 2020 Oct

PMID : 32562269






2 Functional Relationships(s)
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1 KEY RESULTS: 4-AA reduced capsaicin-induced nociceptive behaviour in naive and inflamed conditions through the CB1 receptor. Capsaicin cannabinoid receptor 1 Homo sapiens
2 4-AA (100 muM) reduced capsaicin-induced increase in [Ca2+ ]i in a CB1 receptor-dependent manner when PGE2 was not present. Capsaicin cannabinoid receptor 1 Homo sapiens