Pub. Date : 2020 Jun 19
PMID : 32561715
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Leucine regulates autophagy via acetylation of the mTORC1 component raptor. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | While leucine (Leu) is a critical mTORC1 regulator under AA-starved conditions, how Leu regulates autophagy is poorly understood. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | While leucine (Leu) is a critical mTORC1 regulator under AA-starved conditions, how Leu regulates autophagy is poorly understood. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 4 | Thus, in most cell types we examined, Leu regulates autophagy via the impact of its metabolite AcCoA on mTORC1, suggesting that AcCoA and EP300 play pivotal roles in cell anabolism and catabolism. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |