Title : Role of JAK-STAT signaling in the pathogenic behavior of fibroblast-like synoviocytes in rheumatoid arthritis: Effect of the novel JAK inhibitor peficitinib.

Pub. Date : 2020 Sep 5

PMID : 32561292






1 Functional Relationships(s)
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1 Peficitinib inhibited STAT3 phosphorylation in RA-FLS following induction by interferon (IFN)-alpha2b, IFN-gamma, interleukin (IL)-6, oncostatin M, and leukemia inhibitory factor in a concentration-related manner, and was comparable to approved JAK inhibitors, tofacitinib and baricitinib. peficitinib interferon gamma Homo sapiens