Title : In vitro profiling of the potential endocrine disrupting activities affecting steroid and aryl hydrocarbon receptors of compounds and mixtures prevalent in human drinking water resources.

Pub. Date : 2020 Nov

PMID : 32554009






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 While fluoranthene and phenanthrene strongly reduced human AhR and AR transactivation, benzo [a]pyrene strongly activated AhR and ER, but inhibited GR and AR. Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens
2 In human breast cancer cells, benzo [a]pyrene dramatically activated AhR, inducing a 10-fold higher response than 2,3,7,8-tetrachlorodibenzodioxin (TCDD) at concentrations possibly found realistically in human blood. Benzo(a)pyrene aryl hydrocarbon receptor Homo sapiens