Title : Dimethyl fumarate prevents osteoclastogenesis by decreasing NFATc1 expression, inhibiting of erk and p38 MAPK phosphorylation, and suppressing of HMGB1 release.

Pub. Date : 2020 Sep 17

PMID : 32553625






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Dimethyl fumarate (DMF) is a potent activator of Nrf2 and has been shown to inhibit osteoclastogenesis. Dimethyl Fumarate NFE2 like bZIP transcription factor 2 Homo sapiens
2 Dimethyl fumarate (DMF) is a potent activator of Nrf2 and has been shown to inhibit osteoclastogenesis. Dimethyl Fumarate NFE2 like bZIP transcription factor 2 Homo sapiens
3 We also found that DMF inhibited the extracellular release of high mobility group box 1, associated with an up-regulation of heme oxygenase-1, likely mediated through Nrf2 activation. Dimethyl Fumarate NFE2 like bZIP transcription factor 2 Homo sapiens