Pub. Date : 2020 Oct
PMID : 32552228
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 3-Methyladenine Alleviates Experimental Subretinal Fibrosis by Inhibiting Macrophages and M2 Polarization Through the PI3K/Akt Pathway. | 3-methyladenine | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Mechanistically, we proved that 3-MA inhibits macrophage M2 polarization by suppressing PI3K/Akt signal pathway rather than the PI3K-autophagy-related signal pathway. | 3-methyladenine | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Conclusions: 3-MA exerts antifibrotic effects on experimental SRF by targeting circulating and local macrophages and M2 polarization, through PI3K/Akt signal pathway. | 3-methyladenine | thymoma viral proto-oncogene 1 | Mus musculus |