Title : A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker.

Pub. Date : 2020 Jul 21

PMID : 32551505






1 Functional Relationships(s)
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1 The assay is capable of simultaneously quantifying multiple endogenous compounds, including IBC, thiamine, N1-methylnicotinamide (1-NMN), creatinine, carnitine, and metformin, a substrate for OCT1/2 and MATE1/2K in clinical studies. Metformin solute carrier family 22 member 1 Homo sapiens