Title : Hyaluronic acid promotes Lgr5+ stem cell proliferation and crypt fission through TLR4 and PGE2 transactivation of EGFR.

Pub. Date : 2020 Jul 1

PMID : 32538139






1 Functional Relationships(s)
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1 In WT mice, treatment with NS-398 (a COX2 inhibitor), clodronate (a macrophage-depleting agent), or tyrphostin (an EGFR inhibitor) resulted in 30% reductions in crypt fission and Lgr5+ stem cell proliferation compared with control mice. Tyrphostins epidermal growth factor receptor Mus musculus