Title : Evidence for NAD+-dependent histone dynamics and tunneling associated conformational transitions in circadian deacetylase SIRT1.

Pub. Date : 2020 Sep

PMID : 32531731






1 Functional Relationships(s)
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1 These data suggest that H4KAC16 binding to SIRT1 may coordinate an unusual conformational readjustment of nicotinamide ring at site-b and reposition of HIS363 to facilitate SIRT1-dependent deacetylase activity. Niacinamide sirtuin 1 Homo sapiens