Pub. Date : 2020 Jun 9
PMID : 32526964
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System. | Benzo(a)pyrene | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | In addition, BAI activated antioxidative system nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase 1 (HMOX1), leading the reduction of BaP-induced ROS production. | Benzo(a)pyrene | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | In addition, BAI activated antioxidative system nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase 1 (HMOX1), leading the reduction of BaP-induced ROS production. | Benzo(a)pyrene | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | These results indicate that BAI and BAI-containing herbal drugs may be useful for inhibiting the toxic effects of BaP via dual AHR-CYP1A1-inhibiting and NRF2-HMOX1-activating activities. | Benzo(a)pyrene | NFE2 like bZIP transcription factor 2 | Homo sapiens |