Title : Elucidation of colon-protective efficacy of diosgenin in experimental TNBS-induced colitis: inhibition of NF-κB/IkB-α and Bax/Caspase-1 signaling pathways.

Pub. Date : 2020 Sep

PMID : 32525764






1 Functional Relationships(s)
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1 Diosgenin significantly decreased (p < 0.05) TNBS-induced elevated colonic oxido-nitrosative damage, myeloperoxidase, hydroxyproline, mRNA expressions of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6, and IFN-gamma) and inflammatory markers (iNOs and COX-2) induced by TNBS. Trinitrobenzenesulfonic Acid myeloperoxidase Rattus norvegicus