Pub. Date : 2020 Jul 24
PMID : 32493769
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suramin and NF449 are IP5K inhibitors that disrupt IP6-mediated regulation of cullin RING ligase and sensitize cancer cells to MLN4924/pevonedistat. | Phytic Acid | inositol-pentakisphosphate 2-kinase | Homo sapiens |
| 2 | Inositol hexakisphosphate (IP6) is an abundant metabolite synthesized from inositol 1,3,4,5,6-pentakisphosphate [Ins(1,3,4,5,6)P5, or IP5] by the single Ins(1,3,4,5,6)P5 2-kinase (IP5K/IPPK). | Phytic Acid | inositol-pentakisphosphate 2-kinase | Homo sapiens |
| 3 | Inositol hexakisphosphate (IP6) is an abundant metabolite synthesized from inositol 1,3,4,5,6-pentakisphosphate [Ins(1,3,4,5,6)P5, or IP5] by the single Ins(1,3,4,5,6)P5 2-kinase (IP5K/IPPK). | Phytic Acid | inositol-pentakisphosphate 2-kinase | Homo sapiens |
| 4 | Inositol hexakisphosphate (IP6) is an abundant metabolite synthesized from inositol 1,3,4,5,6-pentakisphosphate [Ins(1,3,4,5,6)P5, or IP5] by the single Ins(1,3,4,5,6)P5 2-kinase (IP5K/IPPK). | Phytic Acid | inositol-pentakisphosphate 2-kinase | Homo sapiens |
| 5 | Inositol hexakisphosphate (IP6) is an abundant metabolite synthesized from inositol 1,3,4,5,6-pentakisphosphate [Ins(1,3,4,5,6)P5, or IP5] by the single Ins(1,3,4,5,6)P5 2-kinase (IP5K/IPPK). | Phytic Acid | inositol-pentakisphosphate 2-kinase | Homo sapiens |
| 6 | Both suramin and NF449 disrupted IP6-dependent sequestration of CRL by the deneddylase COP9 Signalosome (CSN), thereby affecting CRL activity cycle and component dynamics in an IP5K-dependent manner. | Phytic Acid | inositol-pentakisphosphate 2-kinase | Homo sapiens |