Title : Increasing the Hindgut Carbohydrate/Protein Ratio by Cecal Infusion of Corn Starch or Casein Hydrolysate Drives Gut Microbiota-Related Bile Acid Metabolism To Stimulate Colonic Barrier Function.

Pub. Date : 2020 Jun 2

PMID : 32487741






5 Functional Relationships(s)
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1 Caco-2 cell experiments further showed that DCA and LCA downregulated expression of genes involved in barrier function (ZO-1 and OCLD) and upregulated the gene expression of EGFR and Src. Lithocholic Acid SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens
2 Inhibition of EGFR and Src could abolish DCA- and LCA-induced downregulation of ZO-1, indicating that DCA and LCA impair gut barrier function via enhancing the EGFR-Src pathway. Lithocholic Acid SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens
3 Inhibition of EGFR and Src could abolish DCA- and LCA-induced downregulation of ZO-1, indicating that DCA and LCA impair gut barrier function via enhancing the EGFR-Src pathway. Lithocholic Acid SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens
4 Inhibition of EGFR and Src could abolish DCA- and LCA-induced downregulation of ZO-1, indicating that DCA and LCA impair gut barrier function via enhancing the EGFR-Src pathway. Lithocholic Acid SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens
5 Inhibition of EGFR and Src could abolish DCA- and LCA-induced downregulation of ZO-1, indicating that DCA and LCA impair gut barrier function via enhancing the EGFR-Src pathway. Lithocholic Acid SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens