Pub. Date : 2020 May 29
PMID : 32485912
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Roles of JNK/Nrf2 Pathway on Hemin-Induced Heme Oxygenase-1 Activation in MCF-7 Human Breast Cancer Cells. | Hemin | heme oxygenase 1 | Homo sapiens |
| 2 | In this study, we investigated that the mechanisms of hemin-induced HO-1 expression and its signaling pathways in human breast cancer cell. | Hemin | heme oxygenase 1 | Homo sapiens |
| 3 | Hemin increased HO-1 expression in MCF-7 cells in a dose- and time-dependent manner. | Hemin | heme oxygenase 1 | Homo sapiens |
| 4 | Hemin enhanced HO-1 expression through the activation of c-Jun N-terminal kinases (JNK) signaling pathway. | Hemin | heme oxygenase 1 | Homo sapiens |
| 5 | Hemin also induced activation of Nrf2, a major transcription factor of HO-1 expression. | Hemin | heme oxygenase 1 | Homo sapiens |
| 6 | These results indicated that brazilin inhibits hemin-induced HO-1 expressions through inactivation of JNK/Nrf2 in MCF-7 cells. | Hemin | heme oxygenase 1 | Homo sapiens |